Using Finasteride: A look at hair loss treatment with Finasteride

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Finasteride

Finasteride is a drug used for the treatment of manís baldness defects like benign prostatic hypertrophy (BPH) and alopecia areata. BPH is another name for prostate gland enlargement. Prostate is situated close to the bladder and its enlargement causes problems with the passage of urine.

Alopecia areata is the result of an abnormality that causes a disruption in the growth cycle of hair follicle forcing them to enter in dormant stage. This leads to an occurrence of regular falling out of hairs leaving circular bald patches on the scalp. Finasteride works by increasing the amount of male hormone Dihydrotestosterone (DTH) which increases hair growth and prevent slow hair loss.

Mechanism of action

Finasteride is a synthetic 4-azasteroid compound that acts as a competitive inhibitor of Type II 5a-reductase, an intracellular enzyme that converts the androgen testosterone into 5a-Dihydrotestosterone (DHT). Action Mechanism of Finasteride is based on its favored inhibition of Type II 5a-reductase through the formation of a stable complex with the enzyme. This type of inhibition blocks the peripheral conversion of testosterone to DTH, bringing about a significant decrease in DTH concentration of serum and tissues. Since, DTH is the principle androgen responsible for the prostatic growth, a decrease in its concentration with the help of Finasteride results in reduction of prostatic volume. In summation, it results in inhibition of prostate glandís growth by blocking the synthesis of DTH hormone.

How should Finasteride be used?

Finasteride is taken orally once a day with or without food. It should be taken at a same time every day, either in the morning or before sleeping. It should be taken as directed by physician or a medical practitioner. During the treatment of BPH, Finasteride should be taken for at least 6 months to witness effective symptoms whereas while treating male pattern hair loss, Finasteride is prescribed for minimum of 3 months. It is important to note that Finasteride shows improvement only while u take it and one should not stop its dosage even after noticing an improvement. In case, if someone takes Finasteride for 12 months and there is no improvement in hair growth as such, itís better to consult an experienced physician about the continuation of the treatment. Use of Finasteride should be avoided in patients having liver function abnormalities.

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